AUTHOR=Huang Wei , Wang Sibao , Jacobs-Lorena Marcelo 

TITLE=Use of Microbiota to Fight Mosquito-Borne Disease

JOURNAL=Frontiers in Genetics

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2020.00196

DOI=10.3389/fgene.2020.00196

ISSN=1664-8021

ABSTRACT=<p>Mosquito-borne diseases cause more than 700 million people infected and one million people die (<xref ref-type="bibr" rid="B7">Caraballo and King, 2014</xref>). With the limitations of progress toward elimination imposed by insecticide- and drug-resistance, combined with the lack of vaccines, innovative strategies to fight mosquito-borne disease are urgently needed. In recent years, the use of mosquito microbiota has shown great potential for cutting down transmission of mosquito-borne pathogens. Here we review what is known about the mosquito microbiota and how this knowledge is being used to develop new ways to control mosquito-borne disease. We also discuss the challenges for the eventual release of genetically modified (GM) symbionts in the field.</p>