AUTHOR=Mai Meifang , Jiang Yinlian , Wu Xiaoman , Liu Gengrong , Zhu Yaoli , Zhu Weiping 

TITLE=Association of TGF-β1, IL-4, and IL-10 Polymorphisms With Chronic Kidney Disease Susceptibility: A Meta-Analysis

JOURNAL=Frontiers in Genetics

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2020.00079

DOI=10.3389/fgene.2020.00079

ISSN=1664-8021

ABSTRACT=<sec><title>Background</title><p>Anti-inflammatory cytokine polymorphisms in the transforming growth factor-β1 (<italic>TGF-β1</italic>), interleukin-4 (<italic>IL-4</italic>), and <italic>IL-10</italic> genes have been implicated as risk factors for chronic kidney disease (CKD), but the results from published studies are inconsistent. Our meta-analysis reviews and summarizes the cumulative evidence for these associations.</p></sec><sec><title>Methods</title><p>A systematic literature search of five databases was performed up to October 2019. Two authors independently extracted data and evaluated the quality of included studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were generated from random-effects or fixed-effects models using Stata 12.0.</p></sec><sec><title>Results</title><p>Nineteen studies from 10 countries satisfied our inclusion criteria and were included in the meta-analysis. Overall, the pooled analysis showed that <italic>TGF-β1</italic> rs1800469 was associated with decreased susceptibility to CKD (CC + TC <italic>vs</italic>. TT, OR = 0.33, 95% CI: 0.15–0.76, P = 0.009; CC <italic>vs</italic>. TT, OR = 0.33, 95% CI: 0.15–0.73, P = 0.006), whereas <italic>TGF-β1</italic> rs1800471 was associated with increased CKD susceptibility (CC <italic>vs</italic>. CG + GG, OR = 1.68, 95% CI: 1.02–2.77, P = 0.041). In stratified analyses based on ethnicity, <italic>TGF-β1</italic> rs1800469 was associated with CKD susceptibility in Asians and Caucasians, and there was an association of <italic>TGF-β1</italic> rs1800470 and <italic>IL-4</italic> rs8179190 with CKD in Asians. Stratified analyses also associated <italic>TGF-β1</italic> rs1800471 with CKD susceptibility in Caucasians. Neither overall meta-analyses nor stratified analyses identified an association of the <italic>IL-10</italic> rs1800869 and rs1800871 polymorphisms with susceptibility to CKD.</p></sec><sec><title>Conclusions</title><p>Available data suggest that common polymorphisms in the <italic>TGF-β1</italic> and <italic>IL-4</italic> genes including rs1800469, rs1800470, rs1800471, and rs8179190 may be important genetic contributors to CKD susceptibility.</p></sec>