AUTHOR=Minervini Crescenzio Francesco , Cumbo Cosimo , Orsini Paola , Anelli Luisa , Zagaria Antonella , Specchia Giorgina , Albano Francesco TITLE=Nanopore Sequencing in Blood Diseases: A Wide Range of Opportunities JOURNAL=Frontiers in Genetics VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2020.00076 DOI=10.3389/fgene.2020.00076 ISSN=1664-8021 ABSTRACT=

The molecular pathogenesis of hematological diseases is often driven by genetic and epigenetic alterations. Next-generation sequencing has considerably increased our genomic knowledge of these disorders becoming ever more widespread in clinical practice. In 2012 Oxford Nanopore Technologies (ONT) released the MinION, the first long-read nanopore-based sequencer, overcoming the main limits of short-reads sequences generation. In the last years, several nanopore sequencing approaches have been performed in various “-omic” sciences; this review focuses on the challenge to introduce ONT devices in the hematological field, showing advantages, disadvantages and future perspectives of this technology in the precision medicine era.