AUTHOR=Zhou Chao , Li Wentao , Shao Jinchen , Zhao Jikai , Chen Chang 

TITLE=Analysis of the Clinicopathologic Characteristics of Lung Adenocarcinoma With CTNNB1 Mutation

JOURNAL=Frontiers in Genetics

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2019.01367

DOI=10.3389/fgene.2019.01367

ISSN=1664-8021

ABSTRACT=<sec><title>Introduction</title><p>Lung adenocarcinoma with <italic>CTNNB1</italic> mutation is relatively uncommon, and its clinicopathologic characteristics, disease course, and prognosis have not been well-studied.</p></sec><sec><title>Methods</title><p>A total of 564 lung adenocarcinoma patients were enrolled in this study. The relationship between <italic>CTTNB1</italic> mutational status and clinicopathologic parameters, the rates of relapse-free survival (RFS) and overall survival (OS), and the mutational status of other genes commonly mutated in lung adenocarcinoma were analyzed.</p></sec><sec><title>Results</title><p>Of 564 lung adenocarcinoma patients, 30 (5.3%) harbored <italic>CTNNB1</italic> mutations. Univariate analyses revealed that gender, smoking history, pleural invasion, and histological subtype were all significant predictors of RFS and OS. Pleural invasion and histological subtype remained significant predictors of RFS and OS in a multivariate analysis. There were no significant differences in RFS (<italic>p</italic> = 0.504) or OS (<italic>p</italic> = 0.054) between lung adenocarcinoma patients with <italic>CTNNB1</italic> mutation and those without <italic>CTNNB1</italic> mutation. However, patients with <italic>CTNNB1</italic> mutation tended to have a worse OS.</p></sec><sec><title>Conclusions</title><p>Female patients and nonsmokers are likely to harbor <italic>CTNNB1</italic> mutation and primary lung adenocarcinoma with mutated <italic>CTNNB1</italic> has a poor prognosis.</p></sec>