AUTHOR=Zheng Rong , Yao Qiwei , Li XiaoBo , Xu Benhua 

TITLE=Long Noncoding Ribonucleic Acid SNHG18 Promotes Glioma Cell Motility via Disruption of α-Enolase Nucleocytoplasmic Transport

JOURNAL=Frontiers in Genetics

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2019.01140

DOI=10.3389/fgene.2019.01140

ISSN=1664-8021

ABSTRACT=<p>Glioma is a common malignancy with poor prognosis. Recent evidence suggests that the pathogenesis and progression of glioma involve long noncoding RNAs (lncRNAs). Previously, we showed that glioma cell radioresistance was enhanced by lncRNA <italic>SNHG18 in vitro</italic> and <italic>in vivo</italic>. In the present study, we showed that <italic>SNHG18</italic> promoted the invasion and migration of glioma cells. <italic>SNHG18</italic> was demonstrated to regulate the progression of epithelial-mesenchymal transition and cytoskeleton remodeling, thereby affecting cell motility. Furthermore, the promotion of invasion evoked by <italic>SNHG18</italic> overexpression could be rescued by α-enolase (ENO1) deletion. Moreover, rather than altering ENO1 expression, <italic>SNHG18</italic> suppressed its nucleocytoplasmic transport by directly combining with ENO1 in glioma cells. The results suggested that <italic>SNHG18</italic> inhibited the nucleocytoplasmic transport of ENO1 to promote cell motility. The results reveal the mechanism by which this lncRNA affects tumorigenesis and metastasis, forming the basis for further research that will lead to novel strategies to treat glioma.</p>