AUTHOR=Qiao Zhiwei , Jiang Ying , Wang Ling , Wang Lei , Jiang Jing , Zhang Jingru 

TITLE=Mutations in KIAA1109, CACNA1C, BSN, AKAP13, CELSR2, and HELZ2 Are Associated With the Prognosis in Endometrial Cancer

JOURNAL=Frontiers in Genetics

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2019.00909

DOI=10.3389/fgene.2019.00909

ISSN=1664-8021

ABSTRACT=<p>Endometrial cancer (EC) is one of the most common gynecologic malignancies. Emerging studies had demonstrated the mutations in genes could serve as diagnostic or prognostic markers for human cancers. In this study, we screened mutated genes in EC and found that the mutations in <italic>KIAA1109, CACNA1C, BSN, AKAP13, CELSR2,</italic> and <italic>HELZ2</italic> were correlated to the overall survival time in patients with EC. Bioinformatics analysis showed <italic>KIAA1109</italic> was involved in regulating NIK/NF-kappaB signaling, <italic>CACNA1C</italic> was found to regulate cell migration and proliferation, <italic>BSN</italic> was found to regulate Wnt signaling pathway, <italic>CELSR2</italic> was involved in regulating cell–cell adhesion, nuclear import, and protein folding, <italic>HELZ2</italic> was found to regulate multiple immune related biological processes, and <italic>AKAP13</italic> was involved in regulating translation, mRNA nonsense-mediated decay, rRNA processing, translational initiation, and mRNA splicing <italic>via</italic> spliceosome. The findings provided a novel therapeutic strategy in patients with EC.</p>