AUTHOR=Beltrán-García Jesús , Osca-Verdegal Rebeca , Mena-Mollá Salvador , García-Giménez José Luis 

TITLE=Epigenetic IVD Tests for Personalized Precision Medicine in Cancer

JOURNAL=Frontiers in Genetics

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2019.00621

DOI=10.3389/fgene.2019.00621

ISSN=1664-8021

ABSTRACT=<p>Epigenetic alterations play a key role in the initiation and progression of cancer. Therefore, it is possible to use epigenetic marks as biomarkers for predictive and precision medicine in cancer. Precision medicine is poised to impact clinical practice, patients, and healthcare systems. The objective of this review is to provide an overview of the epigenetic testing landscape in cancer by examining commercially available epigenetic-based <italic>in vitro</italic> diagnostic tests for colon, breast, cervical, glioblastoma, lung cancers, and for cancers of unknown origin. We compile current commercial epigenetic tests based on epigenetic biomarkers (i.e., DNA methylation, miRNAs, and histones) that can actually be implemented into clinical practice.</p>