AUTHOR=Bergland Anne Katrine , Soennesyn Hogne , Dalen Ingvild , Rodriguez-Mateos Ana , Berge Rolf Kristian , Giil Lasse Melvaer , Rajendran Lawrence , Siow Richard , Tassotti Michele , Larsen Alf Inge , Aarsland Dag 

TITLE=Effects of Anthocyanin Supplementation on Serum Lipids, Glucose, Markers of Inflammation and Cognition in Adults With Increased Risk of Dementia – A Pilot Study

JOURNAL=Frontiers in Genetics

VOLUME=Volume 10 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2019.00536

DOI=10.3389/fgene.2019.00536

ISSN=1664-8021

ABSTRACT=<sec><title>Background</title><p>Anthocyanins may protect against cardiovascular related cognitive decline and dementia.</p></sec><sec><title>Objective</title><p>Open-label study to measure changes in serum lipids, glucose, glycosylated hemoglobin (HbA1c), and markers of inflammation after anthocyanin supplementation in people with increased risk of dementia. As a secondary endpoint we examined potential changes in a battery of cognitive test in the anthocyanin group (AG). A total of 27 individuals with mild cognitive impairment (MCI) (<italic>n</italic> = 8) or stable non-obstructive coronary artery disease (CAD) (<italic>n</italic> = 19) consumed two Medox<sup>®</sup> capsules, each containing 80 mg of natural purified anthocyanins, twice daily for 16 weeks. They provided blood samples and performed a short battery of cognitive tests. Twenty healthy normal controls (NC) (<italic>n</italic> = 20) provided blood samples, but did not receive any intervention and did not perform cognitive tests.</p></sec><sec><title>Results</title><p>There was a significant difference between groups for monocyte chemoattractant protein (MCP-1) and fasting glucose. In addition, total cholesterol and triglycerides were significantly increased in the AG. Improvements in memory and executive test scores were observed. No adverse effects were reported.</p></sec><sec><title>Conclusion</title><p>The results of this pilot study were largely inconclusive with regard to the potential protective effects of anthocyanin supplementation. However, anthocyanins were well tolerated, and compliance was high. Larger, placebo-controlled studies to explore the potential effects of anthocyanins on dementia risk are encouraged.</p></sec><sec><title>Clinical Trial Registration</title><p><ext-link ext-link-type="uri" xlink:href="http://www.ClinicalTrials.gov" xmlns:xlink="http://www.w3.org/1999/xlink">www.ClinicalTrials.gov</ext-link>, identifier NCT02409446</p></sec>