AUTHOR=Zhang Jie , Wei Zhi , Cardinale Christopher J. , Gusareva Elena S. , Van Steen Kristel , Sleiman Patrick , International IBD Genetics Consortium , Hakonarson Hakon TITLE=Multiple Epistasis Interactions Within MHC Are Associated With Ulcerative Colitis JOURNAL=Frontiers in Genetics VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2019.00257 DOI=10.3389/fgene.2019.00257 ISSN=1664-8021 ABSTRACT=
Successful searching for epistasis is much challenging, which generally requires very large sample sizes and/or very dense marker information. We exploited the largest Crohn's disease (CD) dataset (18,000 cases + 34,000 controls) and ulcerative colitis (UC) dataset (14,000 cases + 34,000 controls) to date. Leveraging its dense marker information and the large sample size of this IBD dataset, we employed a two-step approach to exhaustively search for epistasis. We detected abundant genome-wide significant (