AUTHOR=Zhou Diana , Zhao Yinghong , Hook Michael , Zhao Wenyuan , Starlard-Davenport Athena , Cook Melloni N. , Jones Byron C. , Hamre Kristin M. , Lu Lu 

TITLE=Ethanol’s Effect on Coq7 Expression in the Hippocampus of Mice

JOURNAL=Frontiers in Genetics

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2018.00602

DOI=10.3389/fgene.2018.00602

ISSN=1664-8021

ABSTRACT=<p>Coenzyme Q (CoQ) is a well-studied molecule, present in every cell membrane in the body, best known for its roles as a mitochondrial electron transporter and a potent membrane anti-oxidant. Much of the previous work was done <italic>in vitro</italic> in yeast and more recent work has suggested that CoQ may have additional roles prompting calls for a re-assessment of its role using <italic>in vivo</italic> systems in mammals. Here we investigated the putative role of Coenzyme Q in ethanol-induced effects <italic>in vivo</italic> using BXD RI mice. We examined hippocampal expression of <italic>Coq7</italic> in saline controls and after an acute ethanol treatment, noting enriched biologic processes and pathways following ethanol administration. We also identified 45 ethanol-related phenotypes that were significantly correlated with <italic>Coq7</italic> expression, including six phenotypes related to conditioned taste aversion and ethanol preference. This analysis highlights the need for further investigation of <italic>Coq7</italic> and related genes <italic>in vivo</italic> as well as previously unrecognized roles that it may play in the hippocampus.</p>