AUTHOR=Robert Francis , Pelletier Jerry TITLE=Exploring the Impact of Single-Nucleotide Polymorphisms on Translation JOURNAL=Frontiers in Genetics VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2018.00507 DOI=10.3389/fgene.2018.00507 ISSN=1664-8021 ABSTRACT=

Over the past 15 years, sequencing of the human genome and The Cancer Genome Atlas (TCGA) project have led to comprehensive lists of single-nucleotide polymorphisms (SNPs) and gene mutations across a large number of human samples. However, our ability to predict the functional impact of SNPs and mutations on gene expression is still in its infancy. Here, we provide key examples to help understand how mutations present in genes can affect translational output.