AUTHOR=Ho Xuan D. , Nguyen Hoang G. , Trinh Le H. , Reimann Ene , Prans Ele , Kõks Gea , Maasalu Katre , Le Van Q. , Nguyen Van H. , Le Nghi T. N. , Phung Phuong , Märtson Aare , Lattekivi Freddy , Kõks Sulev TITLE=Analysis of the Expression of Repetitive DNA Elements in Osteosarcoma JOURNAL=Frontiers in Genetics VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2017.00193 DOI=10.3389/fgene.2017.00193 ISSN=1664-8021 ABSTRACT=
Osteosarcoma (OS) is a rare malignant bone tumor. It affects mostly young persons and has poor outcome with the present treatment. No improvement was observed since the introduction of chemotherapy. The better understanding of osteosarcoma development could indicate better management strategy. Repetitive DNA elements were found to play a role in cancer mechanism especially in epithelial tumors but not yet analyzed in osteosarcoma. We conducted the study to analyse the expression profile of repetitive elements (RE) in osteosarcoma.