AUTHOR=Chan Jason P. , Brown Jaylene , Hark Brandon , Nolan Abby , Servello Dustin , Hrobuchak Hannah , Staab Trisha A. TITLE=Loss of Sphingosine Kinase Alters Life History Traits and Locomotor Function in Caenorhabditis elegans JOURNAL=Frontiers in Genetics VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2017.00132 DOI=10.3389/fgene.2017.00132 ISSN=1664-8021 ABSTRACT=
Sphingolipid metabolism is important to balance the abundance of bioactive lipid molecules involved in cell signaling, neuronal function, and survival. Specifically, the sphingolipid sphingosine mediates cell death signaling, whereas its phosphorylated form, sphingosine-1-phosphate (S1P), mediates cell survival signaling. The enzyme sphingosine kinase produces S1P, and the activity of sphingosine kinase impacts the ability of cells to survive under stress and challenges. To examine the influence of sphingolipid metabolism, particularly enzymes regulating sphingosine and S1P, in mediating aging, neuronal function and stress response, we examined life history traits, locomotor capacities and heat stress responses of young and old animals using the model organism