AUTHOR=Webb Bradley T. , Edwards Alexis C. , Wolen Aaron R. , Salvatore Jessica E. , Aliev Fazil , Riley Brien P. , Sun Cuie , Williamson Vernell S. , Kitchens James N. , Pedersen Kimberly , Adkins Amy , Cooke Megan E. , Savage Jeanne E. , Neale Zoe , Cho Seung B. , Dick Danielle M. , Kendler Kenneth S. 

TITLE=Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students

JOURNAL=Frontiers in Genetics

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2017.00030

DOI=10.3389/fgene.2017.00030

ISSN=1664-8021

ABSTRACT=<p><bold>Background:</bold> Genetic factors impact alcohol use behaviors and these factors may become increasingly evident during emerging adulthood. Examination of the effects of individual variants as well as aggregate genetic variation can clarify mechanisms underlying risk.</p><p><bold>Methods:</bold> We conducted genome-wide association studies (GWAS) in an ethnically diverse sample of college students for three quantitative outcomes including typical monthly alcohol consumption, alcohol problems, and maximum number of drinks in 24 h. Heritability based on common genetic variants (<italic>h</italic><sup>2</sup><sub>SNP</sub>) was assessed. We also evaluated whether risk variants in aggregate were associated with alcohol use outcomes in an independent sample of young adults.</p><p><bold>Results:</bold> Two genome-wide significant markers were observed: rs11201929 in <italic>GRID1</italic> for maximum drinks in 24 h, with supportive evidence across all ancestry groups; and rs73317305 in <italic>SAMD12</italic> (alcohol problems), tested only in the African ancestry group. The <italic>h</italic><sup>2</sup><sub>SNP</sub> estimate was 0.19 (SE = 0.11) for consumption, and was non-significant for other outcomes. Genome-wide polygenic scores were significantly associated with alcohol outcomes in an independent sample.</p><p><bold>Conclusions:</bold> These results robustly identify genetic risk for alcohol use outcomes at the variant level and in aggregate. We confirm prior evidence that genetic variation in <italic>GRID1</italic> impacts alcohol use, and identify novel loci of interest for multiple alcohol outcomes in emerging adults. These findings indicate that genetic variation influencing normative and problematic alcohol use is, to some extent, convergent across ancestry groups. Studying college populations represents a promising avenue by which to obtain large, diverse samples for gene identification.</p>