AUTHOR=Kalisperati Polyxeni , Spanou Evangelia , Pateras Ioannis S. , Korkolopoulou Penelope , Varvarigou Anastasia , Karavokyros Ioannis , Gorgoulis Vassilis G. , Vlachoyiannopoulos Panayiotis G. , Sougioultzis Stavros 

TITLE=Inflammation, DNA Damage, Helicobacter pylori and Gastric Tumorigenesis

JOURNAL=Frontiers in Genetics

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2017.00020

DOI=10.3389/fgene.2017.00020

ISSN=1664-8021

ABSTRACT=<p><italic>Helicobacter pylori (H. pylori)</italic> is a Gram negative bacterium that colonizes the stomach of almost half human population. It has evolved to escape immune surveillance, establishes lifelong inflammation, predisposing to genomic instability and DNA damage, notably double strand breaks. The epithelial host cell responds by activation of DNA damage repair (DDR) machinery that seems to be compromised by the infection. It is therefore now accepted that genetic damage is a major mechanism operating in cases of <italic>H. pylori</italic> induced carcinogenesis. Here, we review the data on the molecular pathways involved in DNA damage and DDR activation during <italic>H. pylori</italic> infection.</p>