AUTHOR=Robin Jérôme D. , Magdinier Frédérique 

TITLE=Physiological and Pathological Aging Affects Chromatin Dynamics, Structure and Function at the Nuclear Edge

JOURNAL=Frontiers in Genetics

VOLUME=7

YEAR=2016

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2016.00153

DOI=10.3389/fgene.2016.00153

ISSN=1664-8021

ABSTRACT=<p>Lamins are intermediate filaments that form a complex meshwork at the inner nuclear membrane. Mammalian cells express two types of Lamins, Lamins A/C and Lamins B, encoded by three different genes, <italic>LMNA</italic>, <italic>LMNB1</italic>, and <italic>LMNB2</italic>. Mutations in the <italic>LMNA</italic> gene are associated with a group of phenotypically diverse diseases referred to as laminopathies. Lamins interact with a large number of binding partners including proteins of the nuclear envelope but also chromatin-associated factors. Lamins not only constitute a scaffold for nuclear shape, rigidity and resistance to stress but also contribute to the organization of chromatin and chromosomal domains. We will discuss here the impact of A-type Lamins loss on alterations of chromatin organization and formation of chromatin domains and how disorganization of the lamina contributes to the patho-physiology of premature aging syndromes.</p>