AUTHOR=Zang Xiao-Li , Han Wei-Qing , Yang Feng-Ping , Ji Kai-Da , Wang Ji-Guang , Gao Ping-Jin , He Guang , Wu Sheng-Nan 

TITLE=Association of a SNP in SLC35F3 Gene with the Risk of Hypertension in a Chinese Han Population

JOURNAL=Frontiers in Genetics

VOLUME=7

YEAR=2016

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2016.00108

DOI=10.3389/fgene.2016.00108

ISSN=1664-8021

ABSTRACT=<p>A recent study suggested that <italic>SLC35F3</italic> which encoded a thiamine transporter was a new candidate gene for hypertension. The goal of this study was to investigate the association between the single-nucleotide polymorphisms (SNPs) in the <italic>SLC35F3</italic> gene and hypertension in a Chinese population. Sanger sequencing was performed in 93 samples to find SNPs in coding regions and intron–exon boundaries in the <italic>SLC35F3</italic> gene. We found eight genetic variants in the coding regions of <italic>SLC35F3</italic> and subsequently genotyped a non-synonymous variant rs34032258 (C &gt; G) in 1060 hypertension patients and 1467 controls. After adjusting for age and gender, multivariate analysis of covariance showed that the variant was associated with hypertensive traits. In detail, diastolic blood pressure (DBP) was 8 mmHg higher, blood urea nitrogen was 12 mmol/L higher, and creatinine was 15 mmol/L lower in G/G group compared with C/C group (<italic>p</italic> = 0.007; 0.012 and 0.029, respectively). Further study suggested that C/G+G/G had higher DBP than C/C genotype in those whose DBP ≥ 90 mmHg (98.02 mmHg vs. 94.04 mmHg, <italic>p</italic> = 0.021). No significant difference has been found in systolic blood pressure between different genotypes. Additionally, in the subgroup of obesity, allele distribution of this variant has shown significant difference between hypertensive patients and normotensive controls (<italic>p</italic> = 0.018). In conclusion, we found that the rs34032258 in the <italic>SLC35F3</italic> gene was associated with high blood pressure and may increase the risk of hypertension. The new hypertension-susceptibility locus may involve in the pathogenesis of hypertension and indicate some novel treatment implications.</p>