AUTHOR=Gutierrez Karina , Dicks Naomi , Glanzner Werner G., Agellon Luis B., Bordignon Vilceu 

TITLE=Efficacy of the porcine species in biomedical research

JOURNAL=Frontiers in Genetics

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2015.00293

DOI=10.3389/fgene.2015.00293

ISSN=1664-8021

ABSTRACT=<p>Since domestication, pigs have been used extensively in agriculture and kept as companion animals. More recently they have been used in biomedical research, given they share many physiological and anatomical similarities with humans. Recent technological advances in assisted reproduction, somatic cell cloning, stem cell culture, genome editing, and transgenesis now enable the creation of unique porcine models of human diseases. Here, we highlight the potential applications and advantages of using pigs, particularly minipigs, as indispensable large animal models in fundamental and clinical research, including the development of therapeutics for inherited and chronic disorders, and cancers.</p>