AUTHOR=Mathew Lisha A. , Jensen Jeffrey D. TITLE=Evaluating the ability of the pairwise joint site frequency spectrum to co-estimate selection and demography JOURNAL=Frontiers in Genetics VOLUME=6 YEAR=2015 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2015.00268 DOI=10.3389/fgene.2015.00268 ISSN=1664-8021 ABSTRACT=
The ability to infer the parameters of positive selection from genomic data has many important implications, from identifying drug-resistance mutations in viruses to increasing crop yield by genetically integrating favorable alleles. Although it has been well-described that selection and demography may result in similar patterns of diversity, the ability to jointly estimate these two processes has remained elusive. Here, we use simulation to explore the utility of the joint site frequency spectrum to estimate selection and demography simultaneously, including developing an extension of the previously proposed Jaatha program (