AUTHOR=Wertheim Bregje 

TITLE=Genomic basis of evolutionary change: evolving immunity

JOURNAL=Frontiers in Genetics

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2015.00222

DOI=10.3389/fgene.2015.00222

ISSN=1664-8021

ABSTRACT=<p>Complex traits are manifestations of intricate gene interaction networks. Evolution of complex traits revolves around the genetic variation in such networks. Genomics has increased our ability to investigate the complex gene interaction networks, and characterize the extent of genetic variation in these networks. Immunity is a complex trait, for which the ecological drivers and molecular networks are fairly well understood in <italic>Drosophila</italic>. By characterizing the natural variation in immunity, and mapping how the genome changes during the evolution of immunity in <italic>Drosophila</italic>, we can integrate our knowledge on the complex genetic architecture of traits and the molecular basis of evolutionary processes.</p>