AUTHOR=Chapple Charles E. , Herrmann Carl , Brun Christine TITLE=PrOnto database : GO term functional dissimilarity inferred from biological data JOURNAL=Frontiers in Genetics VOLUME=6 YEAR=2015 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2015.00200 DOI=10.3389/fgene.2015.00200 ISSN=1664-8021 ABSTRACT=
Moonlighting proteins are defined by their involvement in multiple, unrelated functions. The computational prediction of such proteins requires a formal method of assessing the similarity of cellular processes, for example, by identifying dissimilar Gene Ontology terms. While many measures of Gene Ontology term similarity exist, most depend on abstract mathematical analyses of the structure of the GO tree and do not necessarily represent the underlying biology. Here, we propose two metrics of GO term