AUTHOR=Carretero Maria , Gomez-Amaro Rafael L. , Petrascheck Michael 

TITLE=Pharmacological classes that extend lifespan of Caenorhabditis elegans

JOURNAL=Frontiers in Genetics

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2015.00077

DOI=10.3389/fgene.2015.00077

ISSN=1664-8021

ABSTRACT=<p>Recent progress in the field of aging has resulted in ever increasing numbers of compounds that extend lifespan in <italic>Caenorhabditis elegans</italic>. Lifespan extending compounds include metabolites and synthetic compounds, as well as natural products. For many of these compounds, mammalian pharmacology is known, and for some the actual targets have been experimentally identified. In this review, we explore the data available in <italic>C. elegans</italic> to provide an overview of which pharmacological classes have potential for identification of further compounds that extend lifespan.</p>