AUTHOR=Laston Sandra L. , Voruganti V. Saroja , Haack Karin , Shah Vallabh O. , Bobelu Arlene , Bobelu Jeanette , Ghahate Donica , Harford Antonia M. , Paine Susan S. , Tentori Francesca , Cole Shelley A. , MacCluer Jean W. , Comuzzie Anthony G. , Zager Philip G. TITLE=Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: the Zuni Kidney Project JOURNAL=Frontiers in Genetics VOLUME=6 YEAR=2015 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2015.00006 DOI=10.3389/fgene.2015.00006 ISSN=1664-8021 ABSTRACT=
The objective of this study is to identify genetic factors associated with chronic kidney disease (CKD) and related cardiometabolic phenotypes among participants of the Genetics of Kidney Disease in Zuni Indians study. The study was conducted as a community-based participatory research project in the Zuni Indians, a small endogamous tribe in rural New Mexico. We recruited 998 members from 28 extended multigenerational families, ascertained through probands with CKD who had at least one sibling with CKD. We used the Illumina Infinium Human1M-Duo version 3.0 BeadChips to type 1.1 million single nucleotide polymorphisms (SNPs). Prevalence estimates for CKD, hyperuricemia, diabetes, and hypertension were 24%, 30%, 17% and 34%, respectively. We found a significant (