AUTHOR=Belancio Victoria P. , Blask David E. , Deininger Prescott , Hill Steven M. , Jazwinski S. Michal TITLE=The aging clock and circadian control of metabolism and genome stability JOURNAL=Frontiers in Genetics VOLUME=5 YEAR=2015 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2014.00455 DOI=10.3389/fgene.2014.00455 ISSN=1664-8021 ABSTRACT=

It is widely accepted that aging is characterized by a gradual decline in the efficiency and accuracy of biological processes, leading to deterioration of physiological functions and development of age-associated diseases. Age-dependent accumulation of genomic instability and development of metabolic syndrome are well-recognized components of the aging phenotype, both of which have been extensively studied. Existing findings strongly support the view that the integrity of the cellular genome and metabolic function can be influenced by light at night (LAN) and associated suppression of circadian melatonin production. While LAN is reported to accelerate aging by promoting age-associated carcinogenesis in several animal models, the specific molecular mechanism(s) of its action are not fully understood. Here, we review literature supporting a connection between LAN-induced central circadian disruption of peripheral circadian rhythms and clock function, LINE-1 retrotransposon-associated genomic instability, metabolic deregulation, and aging. We propose that aging is a progressive decline in the stability, continuity, and synchronization of multi-frequency oscillations in biological processes to a temporally disorganized state. By extension, healthy aging is the ability to maintain the most consistent, stable, and entrainable rhythmicity and coordination of these oscillations, at the molecular, cellular, and systemic levels.