AUTHOR=Voruganti Venkata Saroja , Kent Jack W., Debnath Subrata , Cole Shelley A., Haack Karin , Goring Harald H., Carless Melanie A., Curran Joanne E., Johnson Matthew P., Almasy Laura , Dyer Thomas D., MacCluer Jean W., Moses Eric K., Abboud Hanna E., Mahaney Michael C., Blangero John , Comuzzie Anthony G. TITLE=Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans JOURNAL=Frontiers in Genetics VOLUME=4 YEAR=2013 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2013.00279 DOI=10.3389/fgene.2013.00279 ISSN=1664-8021 ABSTRACT=
Increased serum uric acid (SUA) is a risk factor for gout and renal and cardiovascular disease (CVD). The purpose of this study was to identify genetic factors that affect the variation in SUA in 632 Mexican Americans participants of the San Antonio Family Heart Study (SAFHS). A genome-wide association (GWA) analysis was performed using the Illumina Human Hap 550K single nucleotide polymorphism (SNP) microarray. We used a linear regression-based association test under an additive model of allelic effect, while accounting for non-independence among family members via a kinship variance component. All analyses were performed in the software package SOLAR. SNPs rs6832439, rs13131257, and rs737267 in solute carrier protein 2 family, member 9 (