AUTHOR=Djansugurova Leyla B., Perfilyeva Anastassiya V., Zhunusova Gulnur S., Djantaeva Kira B., Iksan Olzhas A., Khussainova Elmira M.

TITLE=The Determination of Genetic Markers of Age-Related Cancer Pathologies in Populations from Kazakhstan

JOURNAL=Frontiers in Genetics

VOLUME=4

YEAR=2013

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2013.00070

DOI=10.3389/fgene.2013.00070

ISSN=1664-8021

ABSTRACT=<p>Aging associates with a variety of pathological conditions such as cancer, cardiovascular, neurodegenerative, autoimmune diseases, and metabolic disorders. The oncogenic alterations overlap frequently with the genes linked to aging. Here, we show that several aging related genes may serve as the genetic risk factors for cervical and esophagus cancers. In our study, we analyzed samples obtained from 115 patients with esophageal and 207 patients with cervical cancer. The control groups were selected to match the ethnicity and age of cancer patients. We examined the genes involved in the processes of xenobiotics detoxification (<italic>GSTM1</italic> and <italic>GSTT1</italic>), DNA repair (<italic>XRCC1</italic> and <italic>XRCC3</italic>), and cell cycle regulation and apoptosis (<italic>CCND1</italic> and <italic>TP53</italic>). Our study revealed that deletions of <italic>GSTT1</italic> and <italic>GSTM1</italic> genes or the distinct point mutations of <italic>XRCC1</italic> gene are associated with cervical and esophageal cancers. These results will lead to development of screening for detection of individuals susceptible to esophageal and cervical cancers. Introduction of the screening programs will allow the early and effective preventive measures that will reduce cancer incidence and mortality in Kazakhstan.</p>