AUTHOR=Yu Zuoren , Li Yuan , Fan Huimin , Liu Zhongmin , Pestell Richard G.

TITLE=miRNAs regulate stem cell self-renewal and differentiation

JOURNAL=Frontiers in Genetics

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2012.00191

DOI=10.3389/fgene.2012.00191

ISSN=1664-8021

ABSTRACT=<p>Stem cells undergo symmetric and asymmetric divisions to generate differentiated cells and more stem cells. The balance between self-renewal and differentiation of stem cells is controlled by transcription factors, epigenetic regulatory networks, and microRNAs (miRNAs). Herein the miRNA involvement in the regulation of stem cell self-renewal and differentiation is summarized. miRNA contribution to malignancy through regulating cancer stem cells is described. In addition, the reciprocal associations between miRNAs and epigenetic modifications in control of stem cell fate are discussed.</p>