AUTHOR=Vanneste Evelyne , Bittman Lilach , Van der Aa Niels , Voet Thierry , Vermeesch Joris R.

TITLE=New Array Approaches to Explore Single Cells Genomes

JOURNAL=Frontiers in Genetics

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2012.00044

DOI=10.3389/fgene.2012.00044

ISSN=1664-8021

ABSTRACT=<p>Microarray analysis enables the genome-wide detection of copy number variations and the investigation of chromosomal instability. Whereas array techniques have been well established for the analysis of unamplified DNA derived from many cells, it has been more challenging to enable the accurate analysis of single cell genomes. In this review, we provide an overview of single cell DNA amplification techniques, the different array approaches, and discuss their potential applications to study human embryos.</p>