AUTHOR=Mitra Sheetal A., Mitra Anirban P., Triche Timothy J.

TITLE=A Central Role for Long Non-Coding RNA in Cancer

JOURNAL=Frontiers in Genetics

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2012.00017

DOI=10.3389/fgene.2012.00017

ISSN=1664-8021

ABSTRACT=<p>Long non-coding RNAs (ncRNAs) have been shown to regulate important biological processes that support normal cellular functions. Aberrant regulation of these essential functions can promote tumor development. In this review, we underscore the importance of the regulatory role played by this distinct class of ncRNAs in cancer-associated pathways that govern mechanisms such as cell growth, invasion, and metastasis. We also highlight the possibility of using these unique RNAs as diagnostic and prognostic biomarkers in malignancies.</p>