AUTHOR=Tiwari Hemant K., Patki Amit , Lieberman Jeffrey , Stroup T. Scott , Allison David B., Leibel Rudolph L., Chung Wendy K.

TITLE=Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study)

JOURNAL=Frontiers in Genetics

VOLUME=2

YEAR=2011

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2011.00056

DOI=10.3389/fgene.2011.00056

ISSN=1664-8021

ABSTRACT=<p>Antipsychotic drugs are widely used in treating schizophrenia, bipolar disorder, and other psychiatric disorders. Many of these drugs, despite their therapeutic advantages, substantially increase body weight. We assessed the association of alleles of <italic>31</italic> genes implicated in body weight regulation with weight gain among patients being treated with specific antipsychotic medications in the clinical antipsychotic trials in intervention effectiveness study, we found that rs2237988 in Potassium Channel Inwardly Rectifying Subfamily J Member 11 (<italic>KCNJ11)</italic>, rs13269119 in Solute carrier family 30 member 8 (<italic>SLC30A8</italic>), and rs9922047 in fat mass and obesity associated (FTO) were associated with percent weight gain. We also observed the significant interaction of rs11643744 by treatment effect on the weight gain.</p>