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ORIGINAL RESEARCH article

Front. Gastroenterol.
Sec. Hepatology
Volume 3 - 2024 | doi: 10.3389/fgstr.2024.1455837
This article is part of the Research Topic Women In Gastroenterology: 2024 View all articles

Health-Related-Quality of Life among patients with cirrhosis at a tertiary care center in Addis Ababa, Ethiopia. A cross-sectional study

Provisionally accepted

The final, formatted version of the article will be published soon.

    Abstract Background Health-related quality of life (HRQoL) reflects an individual's perception of how disease and treatment affect their physical, functional, emotional, and social well-being. The burden of cirrhosis is high in Ethiopia but reports on HRQoL among cirrhosis patients are lacking. This study aimed to assess HRQoL and associated factors among patients with cirrhosis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Methods A cross-sectional study was conducted among 221 patients with cirrhosis at Tikur Anbessa Specialized Hospital. Data were coded and entered into Epi Data 4.6.0.2 and analyzed by STATA software version 17m/p. Bivariable and multivariable linear regression analyses were performed. A p-value lower than 0.05 was used to declare statistical significance. Results The mean ±SD age was 42.74 ± 12.25. In multivariable linear regression analysis, Mid Upper Arm Circumference (MUAC) (Standardized β.coff (Std.β.coff) = 0.12, 95% CI (0.06, 0.18), age ≥50 (Std.β.coff = -0.38, 95% CI (-0.68,-0.09), Child-Turcotte-Pugh (CTP) class B (Std.β.coff = -0.92, 95% CI (-1.28, -0.55), CTP class C (Std.β.coff = -1.69, 95% CI (-2.30,-1.07) were significantly associated with mean quality of life score. Conclusion Quality of life score was significantly associated with age, CTP class, and MUAC. Health-related quality of life should be taken into consideration in the assessment and treatment of patients with cirrhosis. Older patients, patients with decompensated cirrhosis, and patients with lower MUAC measurements should be given special attention.

    Keywords: cirrhosis, Child-Turcotte-Pugh (CTP) classification, health-related quality of life, Ethiopia, MUAC (Mid-Upper Arm Circumference)

    Received: 27 Jun 2024; Accepted: 19 Nov 2024.

    Copyright: © 2024 Zewde, Teklemariam, Ayele, Mulu, Agidew and Melaku. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Edgeit Abebe Zewde, Debre Tabor University, Gondar, Ethiopia

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