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SYSTEMATIC REVIEW article

Front. Gastroenterol.
Sec. Hepatology
Volume 3 - 2024 | doi: 10.3389/fgstr.2024.1433324
This article is part of the Research Topic Reviews in Frontiers in Gastroenterology 2024 View all 5 articles

Safety and Efficacy of Plasmapheresis in treatment of Acute Fatty liver of Pregnancy-A systematic review & Meta-analysis

Provisionally accepted
Sujata Siwatch Sujata Siwatch 1*Arka De Arka De 1Bandhanjot Kaur Bandhanjot Kaur 2Divjot S. Lamba Divjot S. Lamba 2Simarpreet Kaur Simarpreet Kaur 2Virendra Singh Virendra Singh 2Aravind P. Gandhi Aravind P. Gandhi 2
  • 1 Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, Haryana, India
  • 2 Department of Obstetrics and Gynecology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

The final, formatted version of the article will be published soon.

    Introduction: Acute fatty liver of pregnancy (AFLP) is a fatal disease occurring in 3rd trimester.The safety and efficacy of plasmapheresis/plasma exchange (PP/PE) as an adjunctive treatment in patients of AFLP has been studied. We performed systematic review and meta-analysis to estimate the clinical parameters that included mortality rates and improvement of the biochemical parameters including Liver and Renal function enzymes, coagulopathy factors of AFLP patients. Methods: We searched PubMed, Ovid MEDLINE, Cochrane, CINAHL and Scopus, ClinicalTrials.gov. RevMan statistical software was used for meta-analysis. Results: Pooled survival proportion for AFLP patients treated with PP/PE was 87.74% (95% CI: 82.84 to 91.65). Safety of PP/PE was studied by its effect on mortality. PE/PP was associated with the reduction in the mortality with pooled odds ratio of 0.51 (95% CI: 0.08 to 3.09) with I 2 =86%. Sensitivity analysis after excluding outlier study, yielded a pooled odds ratio of 0.19 (95% CI: 0.02 to 1.52) with reduced heterogeneity (I² = 63%). Biochemical parameter analysis demonstrated significant improvement post-PP/PE treatment, including decreased bilirubin (

    Keywords: Acute fatty liver of pregnancy, Plasmapheresis, Plasma Exchange, Safety, efficacy, Mortality, Meta-analysis, Biochemical Improvement

    Received: 15 May 2024; Accepted: 25 Jul 2024.

    Copyright: © 2024 Siwatch, De, Kaur, Lamba, Kaur, Singh and Gandhi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Sujata Siwatch, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160 012, Haryana, India

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.