AUTHOR=Serpa Jacinta TITLE=The putative role of gut microbiota in cancer: Cysteine is a pivotal coin JOURNAL=Frontiers in Gastroenterology VOLUME=1 YEAR=2022 URL=https://www.frontiersin.org/journals/gastroenterology/articles/10.3389/fgstr.2022.966957 DOI=10.3389/fgstr.2022.966957 ISSN=2813-1169 ABSTRACT=
Tumor metabolism is mandatory for the proper adaptation of malignant cells to the microenvironment and the acquisition of crucial cellular skills supporting the systemic spread of cancer. Throughout this journey, the contribution of the gut microbiota to the bioavailability of nutrients supporting the bioenergetic and biosynthetic requirements of malignant cells is an issue. This review will focus on the role of cysteine as a coin that mediates the metabolic crosstalk between microbiota and cancer. The key points enclose the way cysteine can be made available by the microbiota, by degradation of more complex compounds or by