Skip to main content

REVIEW article

Front. Epigenet. Epigenom.
Sec. Chromatin Epigenomics
Volume 2 - 2024 | doi: 10.3389/freae.2024.1489362
This article is part of the Research Topic Epigenetics and genomic causality in development and chromatin research View all 4 articles

Lineage-and Stage-Specific Activity of Antigen Receptor Gene Enhancers during Lymphocyte Development

Provisionally accepted
Fei Ma Fei Ma Fatima Zohra Braikia Fatima Zohra Braikia Ranjan Sen Ranjan Sen *
  • National Institute on Aging (NIH), Bethesda, Maryland, United States

The final, formatted version of the article will be published soon.

    Lymphocyte development culminates with generation of mature B and T cells that express unique antigen receptors on the cell surface. Genes that encode the two chains of B or T cell receptors are generated via DNA recombination and expressed sequentially during development, guided by locus activating enhancer sequences. In this review we summarize our understanding of molecular mechanisms that activate these enhancers in a lineage and developmental stage-specific manner. We draw attention to 1) the distinction between chromatin accessibility and transcriptional activation of these loci, 2) incomplete understanding of mechanisms that regulate B versus T cellspecific enhancer activity and 3) transcription factors that contribute to stage-specific enhancer activation within each lineage.

    Keywords: enhancers, Antigen receptor gene, Lymphocyte development, Lineage specific, stage specific, transcription factors (TF)

    Received: 01 Sep 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 Ma, Braikia and Sen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ranjan Sen, National Institute on Aging (NIH), Bethesda, 20892, Maryland, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.