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ORIGINAL RESEARCH article
Front. Epidemiol.
Sec. Epidemiology of Chronic Diseases and Prevention
Volume 5 - 2025 | doi: 10.3389/fepid.2025.1568688
Global, regional, and national burden of multiple myeloma from 1990 to 2021 and projections for 2040: A systematic analysis for the Global Burden of Disease 2021 study
Provisionally accepted- Department of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong Province, China
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Background: Multiple myeloma (MM) is a malignant hematologic disorder characterized by the abnormal clonal proliferation of bone marrow plasma cells and excessive production of immunoglobulins, often leading to severe organ damage. Due to its high incidence, recurrence, and death rates, MM poses a significant burden on individuals and global healthcare systems. This study leverages the latest data from the Global Burden of Disease Study 2021 (GBD 2021) to analyze the epidemiological trends of MM and propose effective preventive strategies. Methods: Using data from GBD 2021, we analyzed the age-standardized incidence rate (ASIR), death rate (ASDR), and disability-adjusted life years (DALYs) of MM, evaluating temporal trends through estimated annual percentage change (EAPC).Pearson correlation analysis was employed to explore the relationship between agestandardized rates (ASRs) and the Sociodemographic Index (SDI). Additionally, frontier analysis was conducted. Finally, Bayesian age-period-cohort models were utilized to predict the trends of MM ASRs through 2040.
Keywords: multiple myeloma1, age-standardized rates2, incidence3, Mortality4, disability-adjusted life years5
Received: 03 Mar 2025; Accepted: 11 Apr 2025.
Copyright: © 2025 Wei, Gao, Wang, Li and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shuqian Xu, Department of Hematology, Qilu Hospital, Shandong University, Jinan, 250012, Shandong Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.