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ORIGINAL RESEARCH article

Front. Epidemiol.
Sec. Infectious Disease Epidemiology
Volume 4 - 2024 | doi: 10.3389/fepid.2024.1310071
This article is part of the Research Topic Insights in Infectious Disease Epidemiology: 2023 View all 3 articles

Outcome of the entomological monitoring for Crimean-Congo haemorrhagic fever virus in the western and southern regions of Kazakhstan in 2021-2022

Provisionally accepted
Nurkeldi Turebekov Nurkeldi Turebekov 1*Talgat Nurmakhanov Talgat Nurmakhanov 1Nur Tukhanova Nur Tukhanova 1Zaure Sayakova Zaure Sayakova 2Veronica Sadovskaya Veronica Sadovskaya 2Alexandr Shevtsov Alexandr Shevtsov 3Gulnara Tokmurziyeva Gulnara Tokmurziyeva 2
  • 1 Laboratory for natural foci viral infections, M.Aikymbayev’s National Scientific Center for Especially Dangerous Infections, Almaty, Kazakhstan
  • 2 M.Aikymbayev’s National Scientific Center for Especially Dangerous Infections, Almaty, Kazakhstan
  • 3 National Center for Biotechnology (Kazakhstan), Nur-sultan, Kazakhstan

The final, formatted version of the article will be published soon.

    The natural foci of Crimean-Congo haemorrhagic fever (CCHF) in Kazakhstan are geographically located in the southern regions of the country (Kyzylorda, Turkestan and Zhambyl regions), where the infection of ticks with the CCHF virus predominantly reside, tick species composition and the number of vectors are monitored annually. The objective of our research was to investigate the genetic variants of the CCHF virus in the southern endemic regions, as well as to monitor the spread of the CCHF virus in the western regions of the country (Aktobe, Atyrau and Mangystau regions). In total, 974 (216 pools) ticks from the western regions and 3527 (583 pools) ticks from the southern regions collected during 2021-2022 were investigated. The presence of CCHF virus was detected by real-time reverse transcription PCR (qRT-PCR) in 1 pool out of 799 pools (0.12%) with Hyalomma scupense ticks captured in the CCHF-endemic Kyzylorda region. In the western regions, CCHF virus was not detected in ticks. The sequencing of incomplete fragments ofthe S, M and L segments ofthe CCHF virus in the detected virus was identified as genotype Asia - I. Phylogenetic analysis showed that the isolate obtained in this study is grouped with the isolate from a patient with CCHF, which we reported in 2015 (KX129738 Genbank). Our findings highlight the importance of including sequencing in the annual monitoring system for better understanding the evolution of the CCHF virus in the study areas of our country.

    Keywords: Formal analysis, visualization, Writing -review & editing. Alexa ndr Shevtsov: Investigation, Writingreview & editing. Talgat Nurmakhanov: Data curation, investigation, methodology, supervision, Writing -original draft. Nurkeldi Turebekov: Data curation

    Received: 09 Oct 2023; Accepted: 22 Jul 2024.

    Copyright: © 2024 Turebekov, Nurmakhanov, Tukhanova, Sayakova, Sadovskaya, Shevtsov and Tokmurziyeva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Nurkeldi Turebekov, Laboratory for natural foci viral infections, M.Aikymbayev’s National Scientific Center for Especially Dangerous Infections, Almaty, Kazakhstan

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