AUTHOR=Todd Jacob L. , Topazian Hillary M. , Zulu Madalitso , Mafunga Pilirani , Mapanje Clement , Kaphatika James G. , Chagomerana Maganizo B. , Hoffman Irving , Juliano Jonathan J. , Mvalo Tisungane TITLE=RTS,S vaccination is associated with reduced parasitemia and anemia among children diagnosed with malaria in the outpatient department of a district hospital in rural Malawi JOURNAL=Frontiers in Epidemiology VOLUME=2 YEAR=2022 URL=https://www.frontiersin.org/journals/epidemiology/articles/10.3389/fepid.2022.1039414 DOI=10.3389/fepid.2022.1039414 ISSN=2674-1199 ABSTRACT=
The RTS,S/AS01 malaria vaccine was recently approved by the World Health Organization, but real-world effectiveness is still being evaluated. We measured hemoglobin concentration and parasite density in vaccinated and unvaccinated children who had been diagnosed with malaria by rapid diagnostic test (mRDT) in the outpatient department of a rural hospital in Malawi. Considering all mRDT positive participants, the mean hemoglobin concentration among unvaccinated participants was 9.58 g/dL. There was improvement to 9.82 g/dL and 10.36 g/dL in the 1 or 2 dose group (