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EDITORIAL article
Front. Endocrinol. , 01 April 2025
Sec. Clinical Diabetes
Volume 16 - 2025 | https://doi.org/10.3389/fendo.2025.1597332
This article is part of the Research Topic Personalized Medicine of Diabetes Retinopathy: From Bench to Bedside View all 10 articles
Editorial on the Research Topic
Personalized medicine of diabetes retinopathy: from bench to bedside
Diabetic retinopathy (DR) stands as a prevalent complication of diabetes mellitus, imposing a substantial burden on individuals worldwide and serving as a leading cause of vision impairment among the middle-aged and elderly populations (1). The progression of DR encompasses various stages, ranging from the initial microvascular alterations to advanced manifestations such as proliferative DR and diabetic macular edema, which significantly compromise visual function (2). Traditionally conceived as primarily a microvascular disorder, emerging evidence underscores the intricate involvement of retinal neurodegeneration in the pathogenesis of DR.
DR is a multifaceted disease driven by a persistent hyperglycemic environment characteristic of diabetes. Beyond microvascular alterations, the pathophysiological mechanisms orchestrating DR onset and progression are diverse and interconnected (3). Genetic predisposition, epigenetic modifications, oxidative stress-induced free radical generation, accumulation of advanced glycosylation end products, inflammatory mediators, and dysregulated vascular endothelial growth factor (VEGF) signaling collectively contribute to the intricate landscape of DR pathogenesis (4). This intricate interplay of molecular pathways underscores the heterogeneous nature of DR, posing a significant challenge in devising tailored therapeutic strategies for individual patients.
The identification of distinct phenotypes of DR, characterized by unique molecular signatures and varying risks for vision-threatening complications, represents a significant breakthrough in patient stratification (5). Molecular profiling techniques, including genomics, proteomics, and metabolomics, have provided valuable insights into the underlying pathophysiological mechanisms of DR (6). By tailoring treatment strategies to match individual patient profiles, personalized medicine holds promise for optimizing therapeutic outcomes and minimizing treatment-related adverse effects.
While anti-VEGF therapy and laser photocoagulation remain the mainstays of treatment for diabetic macular edema and proliferative DR, respectively, personalized medicine offers the opportunity to refine and optimize these approaches. Targeted therapies, guided by the specific molecular characteristics of each patient’s disease, have the potential to enhance treatment efficacy and improve long-term visual outcomes (7, 8). By minimizing treatment burden and maximizing therapeutic benefit, personalized approaches aim to improve patient adherence and quality of life.
Despite the significant progress made in personalized medicine for DR, several challenges remain. Integration of omics technologies into clinical practice presents logistical and technical hurdles, including standardization of methodologies and interpretation of complex data sets (9). Additionally, the cost-effectiveness and accessibility of personalized approaches must be carefully considered to ensure equitable access to care for all patients (10). However, with continued advancements in technology and collaboration between researchers, clinicians, and industry partners, personalized medicine holds the promise of revolutionizing the management of DR and improving outcomes for patients worldwide.
In conclusion, the journey towards personalized medicine in DR represents a transformative paradigm shift, poised to revolutionize our approach to patient care and therapeutic decision-making. By embracing the principles of precision medicine and harnessing the power of molecular profiling and biomarker-driven strategies, we can strive towards optimizing visual outcomes and enhancing the quality of life for individuals afflicted with this sight-threatening complication of diabetes.
KJ: Writing – review & editing, Writing – original draft. HY: Writing – review & editing. WW: Writing – review & editing. AG: Writing – review & editing.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The author(s) declare that no Generative AI was used in the creation of this manuscript.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
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2. Sabanayagam C, Banu R, Chee ML, Lee R, Wang YX, Tan G, et al. Incidence and progression of diabetic retinopathy: a systematic review. Lancet Diabetes Endocrinol. (2019) 7:140–9. doi: 10.1016/S2213-8587(18)30128-1
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6. Wang N, Ding L, Liu D, Zhang Q, Zheng G, Xia X, et al. Molecular investigation of candidate genes for pyroptosis-induced inflammation in diabetic retinopathy. Front Endocrinol. (2022) 13:918605. doi: 10.3389/fendo.2022.918605
7. Van Hove I, Hu TT, Beets K, Van Bergen T, Etienne I, Stitt AW, et al. Targeting RGD-binding integrins as an integrative therapy for diabetic retinopathy and neovascular age-related macular degeneration. Prog retinal eye Res. (2021) 85:100966. doi: 10.1016/j.preteyeres.2021.100966
8. Silva M, Peng T, Zhao X, Li S, Farhan M, Zheng W. Recent trends in drug-delivery systems for the treatment of diabetic retinopathy and associated fibrosis. Advanced Drug delivery Rev. (2021) 173:439–60. doi: 10.1016/j.addr.2021.04.007
9. Du X, Yang L, Kong L, Sun Y, Shen K, Cai Y, et al. Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy. Front Endocrinol. (2022) 13:1037164. doi: 10.3389/fendo.2022.1037164
Keywords: diabetes retinopathy, etiology, biomarker, diagnosis, treatment
Citation: Jin K, Yu H, Wei W and Grzybowski A (2025) Editorial: Personalized medicine of diabetes retinopathy: from bench to bedside. Front. Endocrinol. 16:1597332. doi: 10.3389/fendo.2025.1597332
Received: 21 March 2025; Accepted: 21 March 2025;
Published: 01 April 2025.
Edited and Reviewed by:
Åke Sjöholm, Gävle Hospital, SwedenCopyright © 2025 Jin, Yu, Wei and Grzybowski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Kai Jin, amlua2FpQHpqdS5lZHUuY24=
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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