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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1589485
This article is part of the Research TopicMolecular Biomarkers of Cardiometabolic Disease - Volume IIView all 12 articles
Association of the transferrin receptor to ferritin ratio with the prognosis of patients with acute myocardial infarction-a cross-sectional study
Provisionally accepted- 1Changzhou No.2 People's Hospital, Changzhou, Jiangsu Province, China
- 2Southeast University, Nanjing, Jiangsu Province, China
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Ferroptosis is closely associated with cardiovascular diseases. The present study aimed to evaluate the association between the transferrin receptor (TfR) to ferritin ratio and prognosis in patients with acute myocardial infarction (AMI).In the present study, 600 patients with AMI (TfR/ferritin≥15.3, n = 313, TfR/ferritin<15.3, n = 287) were enrolled, and the primary endpoint was the composite of major adverse cardiovascular events (MACE), which included overall deaths, heart failure, nonfatal MI, nonfatal stroke, and unplanned repeat revascularization (URR). Plasma TfR and ferritin levels were measured at admission and 30 days after discharge.Results: During a median follow-up of 28 months, 80 patients had MACE (68 in the low TfR/ferritin ratio group, and 12 in the high TfR/ferritin ratio group). The Kaplan-Meier survival analyses revealed that the cumulative incidence of MACE, nonfatal stroke, heart failure, nonfatal MI, and URR was higher in the low TfR/ferritin ratio group. In addition, the multivariate Cox and stratification analyses showed that low TfR/ferritin ratio was significantly associated with the increased risk of MACE.Receiver operating characteristic curve analysis revealed that the predictive value of TfR/ferritin ratio at admission and 30 days after discharge was 0.857 and 0.829, respectively. Furthermore, the TfR/ferritin ratio was significantly increased in the dapagliflozin administration group compared with the dapagliflozin-free group at 30 days after discharge, which was an unexpected result.The study results suggest that the TfR/ferritin ratio is an independent risk factor of MACE and provide prognostic information about patients with AMI.
Keywords: TfR, ferritin, AMI, MACE, dapagliflozin
Received: 07 Mar 2025; Accepted: 24 Mar 2025.
Copyright: © 2025 Zhu, Zhang, Jin and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yi Zhu, Changzhou No.2 People's Hospital, Changzhou, Jiangsu Province, China
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