Integrating Perspectives on Obesity, Aging, and Stress

Yuko Maejima ¹ Kenju Shimomura ^1* Heidi de Wet ²

• ¹ Fukushima Medical University, Fukushima, Japan
• ² University of Oxford, Oxford, England, United Kingdom

these interrelated physiological systems. By examining the fields of hormonal, metabolic, and psychological systems, these contributions offer a comprehensive and integrated view of the factors influencing health and disease in the context of obesity, aging, and stress.Various studies within this issue have illuminated the significant roles of body composition and metabolic health in aging processes, highlighting how certain body indices can serve as predictors of important anti-aging markers. This perspective is further enriched by research into the regulatory mechanisms of body composition, emphasizing the therapeutic potential of targeting specific genetic markers and metabolic pathways to manage health. Global research trends on aging associated with periodontal health over the last two decades reveal significant technical advancements, providing a rich backdrop for future research directions in this field. The exploration of psychological factors also proves crucial, as emotional and social support systems are shown to significantly impact glycemic control, particularly in patients managing chronic conditions such as diabetes over a lifetime. These studies highlight that the metal health aspect of dealing with long-term conditions needs as much attention as the management of the physiological pathologies associated with chronic disease.Investigations into hormonal influences reveal that processes beyond traditional sympathetic innervation contribute to the regulation of body weight and adiposity, underscoring the complexity of endocrine interactions. Moreover, novel therapeutic agents have been identified that may offer new avenues for obesity treatment, acting on specific hormonal receptors to reduce energy intake and promote weight loss . Additionally, comprehensive assessments of body composition beyond BMI are emphasized for evaluating health risks, particularly in the context of obesity-related mortality The predictive value of obesity and lipid-related indices in the onset of type 2 diabetes underscores the importance of regular monitoring and early intervention to mitigate health risks.The relationship between metabolic health and cognitive function, particularly in aging populations, is another vital aspect explored in this issue. Findings suggest a clear link between metabolic indices and cognitive performance, highlighting the importance of maintaining metabolic health to preserve cognitive abilities in older adults. Early detection and intervention strategies based on advanced metabolic profiling techniques offer promising pathways to mitigate risks associated with muscle deterioration and cognitive decline. In conclusion, the articles featured in this special issue collectively advance our understanding of the endocrine, metabolic, and psychological factors influencing obesity, aging, and stress.By integrating diverse research methodologies and interdisciplinary approaches, these studies provide a robust foundation for future exploration and innovation in health promotion and disease prevention strategies.