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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1570942
This article is part of the Research Topic Novel Strategies for the Clinical Management of Cardiovascular-Kidney-Metabolic Syndrome View all articles
Quantitative correlation between carotid or lower limb atherosclerosis and coronary heart disease: a retrospective observational study
Provisionally accepted- 1 The Affiliated Hospital of Qingdao University, Qingdao, China
- 2 Qingdao Central Hospital, Qingdao, Shandong Province, China
Background: Early diagnosis and intervention are key for the treatment of coronary heart disease (CHD). Ultrasound is used to assess risk stratification in patients with coronary artery disease. However, few studies quantify the relationship between carotid or lower limb atherosclerosis and coronary revascularization. The purpose of this study is to demonstrate that the semi-quantitative degree of atherosclerosis in the neck or lower extremity vessels can predict the need for coronary revascularization, thereby establishing a predictive model for coronary revascularization based on peripheral vascular disease. Methods: Patients who underwent coronary angiography and peripheral vascular ultrasound were randomly selected for semi-quantitative analysis of the degree of coronary artery and peripheral vascular stenosis. Data from 306 patients were collected. Results: The semiquantitative score, grade score and lower limb score from vascular ultrasound were positively correlated with the Gensini score of coronary artery lesions. The semi-quantitative score (score = 2) predicted the sensitivity and specificity for coronary revascularization at 83.74% and 61.72%, respectively. The graded score (score = 2) predicted the sensitivity and specificity for coronary revascularization at 77.24% and 72.13%, respectively. The lower extremity score (score = 3) predicted the sensitivity and specificity for coronary revascularization at 90.24% and 54.55%, respectively.Conclusions: Carotid semiquantitative scores, grade scores, and lower limb scores are predictive factors for the need for coronary revascularization and can serve as auxiliary examinations for the early diagnosis of coronary artery disease.
Keywords: coronary heart disease, carotid atherosclerosis, Lower limb atherosclerosis, ultrasound, Coronary revascularization, Coronary Angiography
Received: 04 Feb 2025; Accepted: 10 Mar 2025.
Copyright: © 2025 Jiang, Ruan, Zhao, Pan and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shuhan Pan, The Affiliated Hospital of Qingdao University, Qingdao, China
Wenzhong Zhang, The Affiliated Hospital of Qingdao University, Qingdao, China
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