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REVIEW article
Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1570585
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Diabetes mellitus (DM) is a complex metabolic disorder associated with many complications, including diabetic encephalopathy (DE). DE is a severe neurological condition characterized by a progressive decline in cognitive and motor functions, significantly impacting patients' quality of life.Despite advancements in understanding DM, the intricate pathogenetic mechanisms underlying DE remain incompletely elucidated. This review comprehensively analyzes the application of omics technologies to decipher the molecular basis of DE and identify potential diagnostic biomarkers and therapeutic targets. Several studies on animal models of DE have revealed specific metabolic signatures and changes in gene expression in key memory brain regions, like the hippocampus, highlighting potential therapeutic targets. We explore how these "omics" approaches have provided novel insights into the complex interplay of factors contributing to DE. Recurrent alterations were identified upon evaluation of analysis from human tissues and in vitro models of DE. Findings indicate that this pathological condition is characterized by impaired energy metabolism, oxidative stress, neuroinflammation, neuroendocrine dysfunction and the influence of the gut microbiota. A multiomics approach, integrating data from various models and limited human studies, enhances translational understanding of DE pathogenesis, with new implications for diagnosis and treatment.
Keywords: Diabetic encephalopathy 1, omics approaches 2, Oxidative stress 3, neuroinflammation 4, energy metabolism5
Received: 03 Feb 2025; Accepted: 26 Mar 2025.
Copyright: © 2025 Gnoni, Lionetti, Di Lago, Brescia and Bevilacqua. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Antonio Gnoni, University of Bari Aldo Moro, Bari, Italy
Nicoletta Lionetti, University of Bari Aldo Moro, Bari, Italy
Maria Grazia Di Lago, University of Bari Aldo Moro, Bari, Italy
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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