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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1569694
This article is part of the Research TopicA Lifecourse Perspective on Polycystic Ovary Syndrome (PCOS): Bridging Gaps in Research and PracticeView all 17 articles
Evolving Global Trends in PCOS Burden: A Three-Decade Analysis (1990-2021) with Projections to 2036 Among Adolescents and Young Adults
Provisionally accepted- 1Heilongjiang University of Chinese Medicine, Harbin, China
- 2First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
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Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting adolescent and young adult females, yet global data on its burden and trends remains limited.We analyzed data from the Global Burden of Disease Study 2021 for females aged 10-24 years in 204 countries . Metrics included cases, age-standardized incidence (ASIR), prevalence (ASPR), disability-adjusted life years (ASDR), and average annual percentage changes (AAPCs). Future trends (2022-2036) and disease reduction gaps were assessed.From 1990 to 2021, global PCOS cases increased by 56% (incidence), 59% (prevalence), and 58% (DALYs). ASIR rose from 49.45 to 63.26 per 100,000, with an AAPC of 0.8. Southeast Asia, East Asia, and Oceania had the fastest growth, while high-SDI regions bore the highest burden. Girls aged 10-14 showed the steepest agespecific increase. Nationally, the largest increases occurred in Equatorial Guinea, Maldives, and Myanmar, while Italy saw a decline. Forecasts through 2036 indicate continued increases in ASIR (+8.32%), ASPR (+10.87%), and ASDR (+10.39%).Frontier analysis highlighted unachieved reduction potential, especially in high-SDI countries.PCOS burden among adolescents and young adults has significantly risen globally with disparities by region, SDI, and age, warranting urgent and equitable public health strategies.
Keywords: adolescents, Young women, Global burden, pcos, Trends
Received: 01 Feb 2025; Accepted: 14 Apr 2025.
Copyright: © 2025 Wang, Boyu, Li, Meng, Liu, Chen and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ying Guo, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
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