ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1567181
Hashimoto's thyroiditis and its activity status influence the assessment of lymph node metastasis of thyroid cancer
Provisionally accepted
- Tianjin Medical University General Hospital, Tianjin, China
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Background and purpose: Hashimoto's thyroiditis plays a crucial role in the biological behavior of papillary thyroid carcinoma. The purpose of this study was to explore the impact of Hashimoto's thyroiditis on the preoperative evaluation of thyroid cancer.Method: Univariate analysis and multivariate analysis were used to explore the clinicopathological characteristics and risk factors of lymph node metastasis in 2261 papillary thyroid carcinoma patients.The clinical data showed that the clinicopathological characteristics were different in different states of Hashimoto's thyroiditis and the level of TPO antibody(P<0.05). In cases without Hashimoto's thyroiditis, multivariate analysis showed that male sex (OR=1.991, 95%CI:1.574-2.517; P<0.05) were the independent risk factor for lymph node metastasis, while the cases concurrent with Hashimoto's thyroiditis wasn't.The results showed that the area under the ROC curve of the non-Hashimoto's thyroiditis cases was (0.727, 95% CI:0.703-0.752; P<0.05), while in Hashimoto's thyroiditis cases was (0.632, 95% CI:0.590-0.674; P<0.05). Analyzing the differential expression genes in different subgroups, it was found that in males, the differential genes among different LNM statuses were mainly enriched in immune pathways, while in females and the younger genes were mainly enriched in cytokines and kinase pathways, and extracellular matrix in the older.Hashimoto's thyroiditis can affect the preoperative evaluation of thyroid cancer. In addition, sex might affect the biological behavior of papillary thyroid carcinoma, which may result from the different immune status and cellular status among different sexes and age levels.
Keywords: Papillary thyroid carcinoma, Lymph nodes metastasis, Hashimoto's, Immune infiltration, sonography
Received: 26 Jan 2025; Accepted: 24 Apr 2025.
Copyright: © 2025 Yan, Zhao, Zhang and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qinyu Zhang, Tianjin Medical University General Hospital, Tianjin, China
Xianghui He, Tianjin Medical University General Hospital, Tianjin, China
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