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REVIEW article
Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1560396
This article is part of the Research Topic Modifiable Risk Factors for Chronic Kidney Disease Progression View all articles
Hidden Pathway: The Role of Extracellular Matrix in Type 2 Diabetes Mellitus-Related Sarcopenia
Provisionally accepted
Sun Yiping 1
Zepeng Zhang 2
Yufeng Wang 1
Xingquan Wu 2
Yahui Sun 2
Huijuan Lou 2 Jing Xu 1
Junjie Yao 1
Deyu Cong 2*- 1 Changchun University of Chinese Medicine, Changchun, Jilin Province, China
- 2 The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China
Type 2 diabetes mellitus-related sarcopenia (T2DMRS) is a common complication in elderly and advanced diabetes patients that affects long-term prognosis and quality of life. Skeletal muscle is the main unit of glucose metabolism, and it is surrounded by extracellular matrix (ECM), which is a microenvironment that acts as an efficient highway system. The ECM is essential for cellular communication and nutrient transport and supports muscle cell growth and repair. When this "ECM highway" fails to function effectively because of damage or blockage, the development of T2DMRS can be triggered or exacerbated. In recent years, the ECM has been widely demonstrated to play a critical role in insulin resistance and skeletal muscle regeneration. However, how the remodeling of skeletal muscle ECM components specifically affects the T2DMRS mechanism of action has not been scientifically described in detail. In this review, we comprehensively summarize the T2DMRSrelated mechanisms of ECM remodeling, suggesting that collagen and integrins may be potential therapeutic targets.
Keywords: Extracellular Matrix, type 2 diabetes, Sarcopenia, Collagen, Integrins, Skeletal Muscle Regeneration
Received: 14 Jan 2025; Accepted: 27 Mar 2025.
Copyright: © 2025 Yiping, Zhang, Wang, Wu, Sun, Lou, Xu, Yao and Cong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Deyu Cong, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China
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