Editorial: New Insights into the Relationship Between Endocrine Disorders and Dental Diseases

Chaofan Zhang ¹ Shan Jiang ² Nianye Zheng ³ Yunzhi Lin ^1*

• ¹ First Affiliated Hospital of Fujian Medical University, Fuzhou, China
• ² Southern Medical University, Shenzhen Stomatology Hospital, China, Shenzhen, China
• ³ Washington University School of Medicine in St. Louis, USA, st louis, United States

Yang et al.'s study (Yang et al., 2024) conducted a comprehensive cross-sectional study involving 2,530 euthyroid adults, revealing that reduced sensitivity to thyroid hormones (THs) is associated with a heightened risk of periodontitis. Their findings identify serum 25hydroxyvitamin D (25[OH]D) as a mediator in this relationship, suggesting that maintaining adequate levels of 25(OH)D may help modulate thyroid hormone sensitivity and subsequently reduce the risk of periodontitis. This mediation likely operates through 25(OH)D's role in modulating inflammatory pathways and supporting thyroid hormone homeostasis. These insights call for further research to establish causality and explore the therapeutic potential of vitamin D optimization in improving thyroid hormone function and periodontal health.Furthermore, the study by Yan et al. (Yan et al., 2023) illuminates the complex interactions between progesterone supplementation and periodontal health in perimenopausal women. Specifically, the research focused on oral administration of 10 mg dihydroxyprogesterone tablets taken twice daily for 10 days per month over a 6-month period. This targeted progesterone intervention demonstrated a context-dependent inflammatory response: enhancing periodontal inflammation in the absence of scaling and root planing (SRP), yet dampening inflammatory markers when combined with SRP. The findings underscore the nuanced role of hormone supplementation in managing periodontal conditions during the perimenopausal transition." Additionally, debris from extracted teeth without active pathology showed promise as bone graft expanders supporting regeneration, while promoting gingival healing and tissue integration (Xu et al., 2023). The study specifically used premolars extracted for orthodontic reasons from patients with healthy periodontal tissues and no systemic diseases. Further optimization warrants exploring whether inherent signals may be leveraged to improve outcomes.Finally, poor oral health marked by periodontitis and tooth loss associated with increased osteoporotic fractures, whereas routine dental care and hygiene linked to reduced fracture hazards (Park et al., 2023). This reinforces the necessity of coordinated management across dental and skeletal health to mitigate systemic bone complications.Collectively, these findings significantly expanded the current understanding on the relationship between endocrine disorders and dental diseases. Ongoing efforts to translate these findings into coordinated screening and early preventive interventions across medicine and dentistry are critical to alleviate long-term oral-systemic morbidities. Continued mechanistic exploration of connections between endocrine derangements and compromised dental health remains imperative.Key words endocrine disorders, dental diseases, bone remodelling, adipokine, endocrine factors