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EDITORIAL article

Front. Endocrinol.
Sec. Bone Research
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1552950
This article is part of the Research Topic The Endocrine Role of the Musculoskeletal System View all 11 articles

Editorial: The Endocrine Role of the Musculoskeletal System

Provisionally accepted
Siyi Zhu Siyi Zhu 1,2*Giuseppina Storlino Giuseppina Storlino 3Sandeep Kumar Sandeep Kumar 4*
  • 1 Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, China
  • 2 Rehabilitation Medicine Center, Rehabilitation Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 3 Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Apulia, Italy
  • 4 Department of Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States

The final, formatted version of the article will be published soon.

    The musculoskeletal system's dual role as a structural framework and an endocrine organ has 14 unveiled a new frontier in understanding its systemic influence (1)(2)(3). This Research Topic focuses on 15 the endocrine crosstalk between bone and muscle, emphasizing the production and regulation of 16 myokines and osteokines, and their roles in maintaining systemic homeostasis (2-5). The collected 17 studies explore how the musculoskeletal system contributes to both physiological and pathological 18 conditions, enriching the field of endocrinology with innovative insights. 19

    Keywords: Musculoskeletal Endocrinology, bone-muscle crosstalk, Myokines and Osteokines, 12 Systemic Homeostasis, Metabolic Bone Diseases, 13

    Received: 29 Dec 2024; Accepted: 09 Jan 2025.

    Copyright: © 2025 Zhu, Storlino and Kumar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Siyi Zhu, Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, China
    Sandeep Kumar, Department of Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, 35294, Alabama, United States

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