ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Systems Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1545968
The association between the cardiometabolic index and hyperuricemia: 2011-2016 NHANES
Provisionally accepted
- Seventh Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Central obesity is associated with hyperuricemia. However, the association between the cardiometabolic index (CMI), which incorporates abdominal obesity and lipid metabolism parameters to assess central obesity, and hyperuricemia, is unclear. This study aimed to explore the association between CMI and hyperuricemia.We enrolled 5,338 study participants from the 2011-2016 National Health and Nutrition Examination Survey. The participants were divided into three groups based on tertiles of CMI.We performed linear regression and employed weighted logistic regression models, subgroup analyses, and restricted cubic spline (RCS) regression to investigate the association between CMI and hyperuricemia.Results: In this study, 20.4% of the participants were diagnosed with hyperuricemia. A higher CMI correlated consistently with increased serum uric acid levels (β: 0.51; 95% confidence interval (CI): 0.38-0.64) and hyperuricemia (odds ratio (OR): 2.62; 95% CI: 1.91-3.61). In the fully corrected model, for each unit increase in CMI, the incidence of hyperuricemia increased by 54% and serum uric acid levels increased by 0.28 mg/dL. Subgroup analyses showed that the association of CMI with hyperuricemia was stably present in all subgroups. Interaction effects were observed for sex and body mass index subgroup (p for interaction: < 0.05). RCS regression highlighted a significant positive nonlinear association (p < 0.001).Our results indicated a significant positive association between CMI levels and hyperuricemia risk among US adults.
Keywords: NHANES, Central obesity, Cardiometabolic index, Hyperuricemia, Serum uric acid
Received: 16 Dec 2024; Accepted: 22 Apr 2025.
Copyright: © 2025 Zhou, Zou, Cao, Gao, Pi, Tang, Liu and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yang Liu, Seventh Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
Yanghong Zhong, Seventh Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.