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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1544684
Sitagliptin Phosphate Ameliorates Chronic Inflammation In Diabetes Mellitus Via Modulating Macrophage Polarization
Provisionally accepted- the second hospital and clinical medical school，Lanzhou unversity, Lanzhou, China
Recent studies have classified diabetes as a chronic systemic inflammatory metabolic disease, the recruitment, accumulation, and activation polarization of macrophages in metabolic tissues such as adipose tissue and the pancreas play a crucial role in the onset of chronic low-grade inflammation, while macrophages polarization into pro-inflammatory or anti-inflammatory states has distinct metabolic requirements, with mechanistic target of rapamycin (mTOR) kinase signaling and Peroxisome proliferator-activated receptor-γ(PPAR-γ) playing a critical role. Hypoglycemic drugs dipeptidyl peptidase-4 (DPP-4) inhibitors have anti-inflammatory effects, but the specific mechanism is unknown. The results indicated that the mTORc1/PPAR-γ/NF-κB axis participated in the regulation of macrophage polarization in diabetic macrophages models, and that Sitagliptin phosphate treatment promoted the expression of PPAR-γ by inhibiting mTORc1, and enhanced the polarization of M1-type macrophages to M2-type macrophages, which alleviated the chronic inflammation of diabetes. In conclusion, Sitagliptin phosphate improves chronic inflammation in diabetes by regulating macrophage polarization.
Keywords: diabetes, Sitagliptin phosphate, Inflammation, Macrophages, PPAR-γ
Received: 13 Dec 2024; Accepted: 11 Mar 2025.
Copyright: © 2025 Xiaoxia, Yalong and Xinyue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Liu Xinyue, the second hospital and clinical medical school，Lanzhou unversity, Lanzhou, China
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