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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Renal Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1544591
This article is part of the Research Topic Addressing insulin resistance and hyperinsulinemia for cardiovascular disease prevention View all 6 articles
Associations between the triglyceride-glucose index and the risk of heart failure in patients undergoing maintenance hemodialysis: a retrospective cohort study
Provisionally accepted
Qiuyue Zhang 1
Kai Zhou 1
Yuchen Li 1 Yimiao Sun 1 Hui Wu 1 Xiaonan Qiu 1 Ying Zhang 1* Zhiyuan Liu 2*- 1 The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
- 2 Sihong People's Hospital, Suqian, Jiangsu, China
Background: Although the triglyceride-glucose (TyG) index levels have been shown to be a reliable predictor of major adverse cardiovascular events (MACE), few studies have investigated their association with heart failure (HF), especially in patients on dialysis. We therefore aimed to investigate the relationship between the TyG index and the incidence of HF in patients undergoing maintenance hemodialysis (MHD). Methods: A total of 183 participants who underwent MHD in the Blood Purification Center of the Affiliated Hospital of Xuzhou Medical University from September 2008 to October 2023 were included and followed up until March 2024. The TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting blood glucose (mg/dL)/2].Participants were divided into two different groups according to the TyG index. The primary endpoint of this study was newly diagnosed HF events during the follow-up period. Cox proportional hazard models were used to examine the association between the TyG index and the risk of incident HF. To assess the dose-response relationship between TyG index and risk of HF, restricted cubic spline analysis was used.Results: Among the 183 participants, there were 61 incident cases of HF during a median follow-up period of 57 months. In comparison to the group with a lower TyG index, participants with a higher TyG index had a higher risk of HF (HR=2.590, 95%CI=1.490-4.500), regardless of whether a variety of potential confounders were adjusted. The association between TyG index and HF (P for non-linearity ＞ 0.05) was confirmed by restricted cubic spline analysis.The TyG index was positively associated with the risk of incident HF in patients undergoing MHD, which indicates that the TyG index might be useful to identify people at high-risk for developing HF.
Keywords: Triglyceride-glucose index, Heart Failure, Maintenance hemodialysis (MHD), Insulin Resistance, HF-related hospitalizations
Received: 20 Dec 2024; Accepted: 11 Mar 2025.
Copyright: © 2025 Zhang, Zhou, Li, Sun, Wu, Qiu, Zhang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ying Zhang, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Zhiyuan Liu, Sihong People's Hospital, Suqian, Jiangsu, China
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